Name | 4-Trifluoromethoxyaniline |
Synonyms | 4-(TrifluoroMe 4-Trifluoromethoxyaniline 4-Trifluoromethoxy aniline Riluzole Related CoMpound A 4-(Trifluoromethoxy)aniline For trifluoromethoxy aniline The trifluoro Methoxy aniline p-Aminotrifluoromethoxybenzene 4- threedifluoro Methoxyaniline Riluzole Related Compound A (25 mg) (4-trifluoromethoxyaniline) |
CAS | 461-82-5 |
EINECS | 207-317-5 |
InChI | InChI:1S/C7H6F3NO/c8-7(9,10)12-6-3-1-5(11)2-4-6/h1-4H,11H2 |
InChIKey | XUJFOSLZQITUOI-UHFFFAOYSA-N |
Molecular Formula | C7H6F3NO |
Molar Mass | 177.12 |
Density | 1.32g/mLat 20°C(lit.) |
Boling Point | 73-75°C10mm Hg(lit.) |
Flash Point | 177°F |
Vapor Presure | 2.97mmHg at 25°C |
Appearance | Liquid |
Specific Gravity | 1.310 |
Color | Clear colorless to yellow |
BRN | 2090209 |
pKa | 3.75±0.10(Predicted) |
Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
Refractive Index | n20/D 1.463(lit.) |
Physical and Chemical Properties | Density: 1.31 Boiling Point: 73 ° C. (10 mmHg) refractive index: 464 flash point: 80 ° C. |
Use | For the synthesis of fluorine-containing pharmaceutical and pesticide intermediates |
Risk Codes | R24/25 - R33 - Danger of cumulative effects R38 - Irritating to the skin R41 - Risk of serious damage to eyes R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36 - Wear suitable protective clothing. |
UN IDs | UN 2941 6.1/PG 3 |
WGK Germany | 2 |
HS Code | 29222900 |
Hazard Note | Toxic |
Hazard Class | IRRITANT, TOXIC |
Packing Group | III |
Uses | 4-trifluoromethoxyaniline is an intermediate of the insecticide. Used for the synthesis of fluorine-containing medicines, pesticide intermediates, etc. The intermediates for the synthesis of fluorine-containing drugs and pesticides: such as fipronil, fluoroenurea, and antiurea. |
Production method | The preparation method is to reduce 4-trifluoromethoxynitrobenzene to obtain 4-trifluoromethoxyaniline. Or it is prepared by reacting 4-trifluoromethoxybenzamide with bromine in an aqueous solution of potassium hydroxide. |